If you keep records, schedule appointments and carry on other such activities from your home office, some common home-office expenses, such as utilities, insurance, repairs, cleaning and depreciation, may qualify for a deduction, even if you do the actual work in another location. Be aware, however, any depreciation claimed after May 6th, 1997, will be taxed at 25% if the residence is sold for a gain, whether or not the property has been converted for personal use.
There is a simplified home office deduction calculation that was introduced to bypass maintaining detailed expense records. Simply deduct $5 for every square foot of home office space is used, up to a maximum of 300 square feet or $1,500. This simplified expense is recorded on Schedule C rather than Form 8829 which allows you to separately deduct mortgage interest and real estate taxes on Schedule A.
TIP: If you (or your family) use your home office for non-business purposes, it cannot be claimed on your tax return. To claim home-office deductions, the space must be used regularly and exclusively for business purposes.